Forskning på svenska kolorektalcancerregistret

Här finner du information om hur du går tillväga för att ansöka om datauttag för forskning, ansökningsblanketter samt vilka variabler som finns registrerade


I Colorectal Cancer data Base (CRC BaSe) finns omkring 77 000 individer som diagnosticerats med tjock- och ändtarmscancer, samt deras förstagradssläktingar ‒ föräldrar, syskon, barn. I databasen har varje patient sex kontroller, det vill säga slumpvalda personer som ska representera den allmänna befolkningen. Även släktingar till kontrollerna ingår. CRC BaSe har nationell täckning och gör det möjligt att utföra klinisk epidemiologisk forskning som kan leda till bättre vård och prognos för patienter med tjock- och ändtarmscancer.

Publikationer baserade på svenska kolorektalcancerregistret

Axmarker T, Leffler M, Lepsenyi M, Thorlacius H, Syk I. Long-term survival after self-expanding metallic stent or stoma decompression as bridge to surgery in acute malignant large bowel obstruction. BJS Open. 2021 Mar 5;5(2):zrab018
Back E, Häggström J, Holmgren K, Haapamäki MM, Matthiessen P, Rutegård J, Rutegård M. Permanent stoma rates after anterior resection for rectal cancer: risk prediction scoring using preoperative variables. Br J Surg. 2021 Nov 11;108(11):1388–1395 R.R.
Bahadoer, E. Bastiaannet, Y.H.M. Claassen, A.C.R.K. BoS, E. van Eycken, J. Verbeeck, M.G. Guren, H. Kørner, Martling A, R. Johansson, C.J.H van de Velde, J.W. Dekker. One-year excess mortality and treatment in surgically treated patients with colorectal cancer: a EURECCA European comparison. Eur J Surg Oncol 2021 Jul;47(7):1651–1660
Bass GA, Forssten M, Pourlotfi A, Ahl Hulme R, Cao Y, Matthiessen P, Mohseni S. Cardiac risk stratification in emergency resection for colonic tumours. BJS Open. 2021 Jul 6;5(4):zrab057
Bernhoff R, Sjövall A, Granath F, Holm T, Martling A, Buchli C. Oncological outcomes after complete mesocolic excision in right-sided color cancer: a population-based study. Colorectal Disease 2021 June; 23(6):1404–1413
Boström P, Hultberg DK, Häggström J, Haapamäki MM, Matthiessen P, Rutegård J, Rutegård M. Oncological Impact of High Vascular Tie After Surgery for Rectal Cancer: A Nationwide Cohort Study. Ann Surg. 2021 Sep 1;274(3):e236–e244
Boström, P, Svensson, J, Brorsson, C. et al. Early postoperative pain as a marker of anastomotic leakage in colorectal cancer surgery. Int J Colorectal Dis. 2021 Sep;36(9):1955–1963
Båverud Olsson L, Buchli C, Villard C, Nilsson PJ. Differences in management and outcome for colon and rectal carcinoma with synchronous liver metastases: a population-based cohort study. Colorectal Dis. 2021 Apr;23(4):860–867
Eloranta S, Smedby KE, Dickman PW, Andersson TM. Cancer survival statistics for patients and healthcare professionals – a tutorial of real-world data analysis. J Intern Med. 2021 Jan;289(1):12–28.
Falk W, Gupta A, Forssten MP, Hjelmqvist H, Bass GA, Matthiessen P, Mohseni S. Epidural analgesia and mortality after colorectal cancer surgery: A retrospective cohort study. Ann Med Surg (Lond). 2021 May 19;66:102414
Gadan S, Brand JS, Rutegård M, Matthiessen P. Defunctioning stoma and short- and long-term outcomes after low anterior resection for rectal cancer – a nationwide register-based cohort study. Int J Colorectal Dis. 2021 Jul;36(7):1433–1442
Grahn O, Lundin M, Lydrup ML, Angenete E, Rutegård M. Postoperative non-steroidal anti-inflammatory drug use and oncological outcomes of rectal cancer. BJS Open. 2021 Jan 8;5(1):zraa050.
Holmgren K, Häggström J, Haapamäki MM, Matthiessen P, Rutegård J, Rutegård M. Defunctioning stomas may reduce chances of a stoma-free outcome after anterior resection for rectal cancer. Colorectal Dis. 2021 Nov;23(11):2859–2869
Imam I, Hammarström K, Sjöblom T, Glimelius B. Neoadjuvant rectal (NAR) score: Value evaluating the efficacy of neoadjuvant therapy and prognostic significance after surgery? Radiother Oncol. 2021 Apr;157:70–77
Karlsson N, Zackrisson S, Buchwald P. Computed Tomography Verified Prevalence of Incisional Hernia 1 Year Postoperatively after Colorectal Cancer Resection. Scand J Surg. 2021 Sep;110(3):373–379 
Li M, Cao Y, Olsson L. A population-based study on time trends of hemoglobin in primary care comparing prediagnostic colorectal cancer patients vs age- and sex-matched controls. Scand J Gastroenterol. 2021 Mar;56(3):266–273
Lillo-Felipe M, Ahl Hulme R, Sjolin G, Cao Y, Bass GA, Matthiessen P, Mohseni S. Hospital academic status is associated with failure-to-rescue after colorectal cancer surgery. Surgery. 2021 Sep;170(3):863–869
Lillo-Felipe M, Ahl Hulme R, Forssten MP, Bass GA, Cao Y, Matthiessen P, Mohseni S. Center-Level Procedure Volume Does Not Predict Failure-to-Rescue After Severe Complications of Oncologic Colon and Rectal Surgery. World J Surg. 2021 Dec;45(12):3695–3706
Maghami S, Cao Y, Ahl R, Detlofsson E, Matthiessen P, Sarani B, Mohseni S. Beta-blocker Therapy is Associated with Decreased 1-year Mortality After Emergency Laparotomy in Geriatric Patients. Scand J Surg. 2021 Mar;110(1):37–43
Osterman E, Hammarström K, Imam I, Osterlund E, Sjöblom T, Glimelius B. Completeness and accuracy of the registration of recurrences in the Swedish Colorectal Cancer Registry (SCRCR) and an update of recurrence risk in colon cancer. Acta Oncol. 2021 Jul;60(7):842–849
Osterman E, Ekström J, Sjöblom T, Kørner H, Myklebust TÅ, Guren MG, Glimelius B. Accurate population-based model for individual prediction of colon cancer recurrence. Acta Oncol. 2021 Oct;60(10):1241–1249
Pourlotfi A, Ahl R, Sjolin G, Forssten MP, Bass GA, Cao Y, Matthiessen P, Mohseni S. Statin therapy and postoperative short-term mortality after rectal cancer surgery. Colorectal Dis. 2021 Apr;23(4):875–881
Pourlotfi A, Bass GA, Ahl Hulme R, Forssten MP, Sjolin G, Cao Y, Matthiessen P, Mohseni S. Statin Use and Long-Term Mortality after Rectal Cancer Surgery. Cancers (Basel). 2021 Aug 25;13(17):4288
H Ribbing Wilén, D Saraste, J Blom Gender-specific cut-off levels in colorectal cancer screening with fecal immunochemical test: A population-based study of colonoscopy findings and costs Journal of Medical Screening 2021;28(4):439-447
Rosander E, Holm T, Sjövall A, Hjern F, Weibull CE, Nordenvall C. Preoperative multidisciplinary team assessment is associated with improved survival in patients with locally advanced colon cancer; a nationwide cohort study in 3157 patients. Eur J Surg Oncol. 2021 Sep;47(9):2398–2404
Rydbeck D, Asplund D, Bock D, et al. Younger age at onset of colorectal cancer is associated with increased patient's delay. Eur J Cancer 2021; 154:269–276
Sandberg S, Asplund D, Bock D, et al. Predicting life with a permanent end colostomy: A prospective study on function, bother and acceptance. Colorectal Dis 2021; 23(10):2681–2689
Scherman P, Syk I, Holmberg E, Naredi P, Rizell M. Impact of patient, primary tumor and metastatic pattern including tumor location on survival in patients undergoing ablation or resection for colorectal liver metastases: A population-based national cohort study. Eur J Surg Oncol 2021 47(2);375–383
Teurneau-Hermansson K, Svensson Neufert R, Buchwald P, Jörgren F. Rectal washout does not increase the complication risk after anterior resection for rectal cancer. World J Surg Oncol. 2021 Mar 19;19(1):82
Wikner F, Matthiessen P, Sörelius K, Legrell P, Rutegård M. Discrepancy between surgeon and radiological assessment of ligation level of the inferior mesenteric artery in patients operated for rectal cancer – impacting registry-based research and surgical practice. World J Surg Oncol. 2021 Apr 13;19(1):115


Agger EA, Jörgren FH, Lydrup ML, Buchwald, PL. Risk of local recurrence of rectal cancer and circumferential resection margin: population-based cohort study. British Journal of Surgery. 2020 (107);580−585. Ahl R, Matthiessen P, Fang X, Cao Y, Sjolin G, Lindgren R, Ljungqvist O, Mohseni S. β-Blockade in Rectal Cancer Surgery: A Simple Measure of Improving Outcomes. Ann Surg. 2020 Jan;271(1):140−146. 

Ahl R, Matthiessen P, Sjölin G, Cao Y, Wallin G, Ljungqvist O, Mohseni S Effects of beta-blocker therapy on mortality after elective colon cancer surgery: Swedish nationwide cohort study. BMJ Open. 2020 Jul 7;10(7):e 036164. 

Alvfeldt, G, Aspelin P, Blomqvist L, Sellberg N. Rectal cancer staging using MRI: adherence in reporting to evidence-based practice. Acta radiologica. 2020 (11);1463−1472. 

Detering R, Saraste D, de Neree tot Babberich M, Dekker J.W.T, Wouters W.J.M. M, van Geloven A.W. N, Bemelman W. A, Tanis P. J, Martling A, Westerterp M, on behalf of the Swedish ColoRectal Cancer Registry and the Dutch ColoRectal Audit. International evaluation of circumferential resection margins after rectal cancer resection; insights from the Swedish and Dutch audits. Colorectal Dis. 2020 Apr, 22(4):416−429. 

Forsberg A, Widman L, Bottai M, Ekbom A, Hultcrantz R. Post-colonoscopy Colorectal Cancer in Sweden 2003-2012: Survival, Tumor Characteristics, and Risk Factors. Clin Gastroenterol Hepatol. 2020 Nov;18(12):2724−2733.e3. 

Gehrman J, Angenete E, Björholt I, Lesén E, Haglind E. Cost-effectiveness analysis of laparoscopic and open surgery in routine Swedish care for colorectal cancer. Surg Endosc. 2020 Oct;34(10):4403−4412.

Glimelius B, Osterman E. Adjuvant Chemotherapy in Elderly Colorectal Cancer Patients. Cancers (Basel). 2020 (12);2289. Hammarstrom K, Imam I, Mezheyeuski A, Ekstrom J, Sjoblom T, Glimelius B. A Comprehensive Evaluation of Associations Between Routinely Collected Staging Information and The Response to (Chemo)Radiotherapy in Rectal Cancer. Cancers (Basel). 2020 (13);16. 

Jörgren F, Lydrup ML, Buchwald P. Impact of rectal perforation on recurrence during rectal cancer surgery in a national population registry. British Journal of Surgery. 2020 (107);1818−1825. 

Karlsson, L., D. Bock, D. Asplund, B. Ohlsson, J. Rosenberg and E. Angenete. Urinary dysfunction in patients with rectal cancer: a prospective cohort study. Colorectal Dis 2020 22(1): 18−28. 

Daniel Kverneng Hultberg, Johan Svensson, Henrik Jutesten, Jörgen Rutegård, Peter Matthiessen, Marie-Louise Lydrup, Martin Rutegård. The impact of anastomotic leakage on long-term function after anterior resection for rectal Cancer. Diseases of the Colon & Rectum 2020: 63 (5), 619−628 

Osterman E, Mezheyeuski A, Sjoblom T, Glimelius B. Beyond the NCCN Risk Factors in Colon Cancer: An Evaluation in a Swedish Population-Based Cohort. Ann Surg Oncol. 2020 (27);1036−45. 

Osterman E, Hammarstrom K, Imam I, Österlund E, Sjöblom T, Glimelius B. Recurrence Risk After Radical Colorectal Cancer Surgery–Less Than Before, But How High Is It? Cancers. 2020 (12);3308. 

Pesola F, Eloranta S, Martling A, Saraste D, Ekström-Smedby K. Family history of colorectal cancer and survival: A Swedish population-based study. J J Intern Med. 2020 June; 287(6):723-733. 

Petersson J, Bock D, Martling A, Ekström-Smedby K, Angenete E, Saraste D. Increasing incidence of colorectal cancer among the younger population in Sweden. BJS Open 2020 Aug; 4(4):645−658. 

Pourlotfi A, Ahl R, Sjolin G, Forssten MP, Bass GA, Cao Y, Matthiessen P, Mohseni S. Statin therapy and postoperative short-term mortality after rectal cancer surgery. Colorectal Dis. 2020 Dec 11. doi: 10.1111/codi.15481 

Rönnow CF, Arthursson V, Toth E, Krarup PM, Syk I, Thorlacius H. Lymphovascular infiltration, not depth of invasion, is the critical risk factor of metastases in early colorectal cancer. Annals of Surgery. 2020; Mar 13. Online ahead of print. 

Sandberg, S., D. Asplund, T. Bisgaard, D. Bock, E. Gonzalez, L. Karlsson, P. Matthiessen, B. Ohlsson, J. Park, J. Rosenberg, S. Skullman, M. Sorensson and E. Angenete. Low anterior resection syndrome in a Scandinavian population of patients with rectal cancer: a longitudinal follow-up within the QoLiRECT study. Colorectal Dis 2020 22(10): 1367-1378. 

Saraste D, Järås J, Martling A. Population-based analysis of outcomes with early-age colorectal cancer. Br J Surg. 2020 Feb;107(3):301-309.

Scherman P, Syk I, Holmberg E, Naredi P, Rizell M. Influence of primary tumour and patient factors on survival in patients undergoing curative resection and treatment for liver metastases from colorectal cancer. BJS Open 2020 4(1);118-132. 

Sjövall A, Söderqvist L, Martling A, Buchli C. Improvement of colorectal cancer patient experience with a regional cancer plan in Sweden. Colorectal Dis 2020 Aug1;22(12):1965-73. 

Song M, Emilsson L, Bozorg SR, Nguyen LH, Joshi AD, Staller K, Nayor J, Chan AT, Ludvigsson JF. Risk of colorectal cancer incidence and mortality after polypectomy: a Swedish record-linkage study. Lancet Gastroenterol Hepatol. 2020 Jun;5(6):537-547. 

Sorensson, M., D. Asplund, P. Matthiessen, J. Rosenberg, T. Hallgren, C. Rosander, E. Gonzalez, D. Bock and E. Angenete. Self-reported sexual dysfunction in patients with rectal cancer. Colorectal Dis 2020 22(5): 500-512. 

Stormark K, Krarup PM, Sjövall A, Søreide K, Kvaløy JT, Nordholm-Carstensen A, Nedrebø BS, Kørner H. Anastomotic leak after surgery for colon cancer and effect on long-term survival. Colorectal Dis. 2020 Sep;22(9):1108-1118 

Tinguely P, Dal G, Bottai M, Nilsson H, Freedman J, Engstrand J. Microwave ablation versus resection for colorectal cancer liver metastases – A propensity score analysis from a population-based nationwide registry. European Journal of Surgery 2020 Mar; 46(3):476-485 

Walming, S., D. Asplund, D. Bock, E. Gonzalez, J. Rosenberg, K. Smedh and E. Angenete. Quality of life in patients with resectable rectal cancer during the first 24 months following diagnosis. Colorectal Dis 2020 12(22): 2028-2037.


Afshari K, Chabok A, Naredi P, Smedh K, Nikberg M Prognostic factors for survival in stage IV rectal cancer: A Swedish nationwide case-control study. Surg Oncol. 2019 Jun;(29):102–106. 

Ahl R, Matthiessen P, Cao Y, Sjolin G, Ljungqvist O, Mohseni S. The Relationship Between Severe Complications, Beta-Blocker Therapy and Long-Term Survival Following Emergency Surgery for Colon Cancer. World J Surg. 2019 Oct;43(10):2527–2535. 

Arnarson Ö, Butt S, Syk I. Postoperative complication following colonic resection for cancer is associated with impaired long-term survival. Colorectal Dis. 2019 Jul;21(7):805–815. 

Bastiaenen V.P, Hovdenak Jakobsen I, Labianca R, Martling A, Morton D.G, Primrose J.N, Tanis P.J, and Laurberg S, on behalf of the Research Committee of the European Society of Coloproctology (ESCP). Consensus and controversies regarding follow-up after curative intent treatment of non-metastatic colorectal cancer: a guideline synopsis. (Review) Colorectal Dis. 2019 Apr;21(4):392–416. 

Benitez Majano S, Di Girolamo C, Rachet B, Maringe C, Guren MG, Glimelius B, Iversen LH, Schnell EA, Lundqvist K, Christensen J, Morris M, Coleman MP, Walters S. Surgical treatment and survival from colorectal cancer in Denmark, England, Norway, and Sweden: a populationbased study. Lancet Oncol. 2019 Jan;20(1):74–87. 

Bergvall M, Skullman S, Kodeda K, Larsson PA. Better survival for patients with colon cancer operated on by specialized colorectal surgeons – a nationwide population-based study in Sweden 2007–2010. Colorectal Dis. 2019 Dec;21(12):1379–1386. 

P. Boström, M. Haapamäki, J. Rutegård, P. Matthiessen, M. Rutegård. Population‐based cohort study of the impact on postoperative mortality of anastomotic leakage after anterior resection for rectal cancer. BJS Open 2019;3:106–111. 

Claassen Y.H.M, Bastiaannet E, van Eycken E, Van Damme N, Martling A, Johansson R, Iversen L.H, Ingeholm P, Lemmens V.E.P.P, Liefers G.J, Holman F.A, Dekker J.W.T, Portielje J.E.A, Rutten H.J, van de Velde C.J.H. Time trends of short-term mortality for octogenarians undergoing a colorectal resection in North Europe. Eur J Surg Oncol. 2019:45(8):1396–1402. 

D'Souza, N; Lord, A; Shaw, A; Abulafi, M; Kontovounisios, C; Sjövall, A; Tekkis, P; Brown. Meta-analysis of oncological outcomes of sigmoid cancers: A hidden epidemic R1 “palliative” resections. European journal of surgical oncology: the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 2019. Pages 489–497 Volume 45 Issue 4 

Erlandsson J, Pettersson D, Glimelius B, Holm T, Martling A. Postoperative complications in relation to overall treatment time after neo-adjuvant radiotherapy in patients with rectal cancer. Br J Surg. 2019 Aug;106(9):1248–1256. 

Erlandsson J, Lörinc E, Ahlberg M, Holm T, Glimelius B, Martling A. Tumour regression after radiotherapy for rectal cancer - Results from the randomised Stockholm III trial. Radiotherapy and Oncology Volume 135, June 2019, Pages 178–186. 

Gehrman J, Angenete E, Björholt I, Lesén E, Haglind E. Health economic evaluation of laparoscopic versus open surgery for colorectal cancer in Swedish routine care. Surg Endosc 2019 Oct 17. 

Hammarström K, Imam I, Korsavidou Hult N, Ekström J, Sjöblom T, Glimelius B. Determining the use of preoperative (chemo)radiotherapy in primary rectal cancer according to national and international guidelines. Radiother Oncol. 2019 Jul;136:106–112. 

Iveson T, Boyd KA, Kerr RS, Robles-Zurita J, Saunders MP, Briggs AH, Cassidy J, Hollander NH, Tabernero J, Haydon A, Glimelius B, Harkin A, Allan K, McQueen J, Pearson S, Waterston A, Medley L, Wilson C, Ellis R, Essapen S, Dhadda AS, Harrison M, Falk S, Raouf S, Rees C, Olesen RK, Propper D, Bridgewater J, Azzabi A, Farrugia D, Webb A, Cunningham D, Hickish T, Weaver A, Gollins S, Wasan H, Paul J. 3-month versus 6-month adjuvant chemotherapy for patients with high-risk stage II and III colorectal cancer: 3-year follow-up of the SCOT non-inferiority RCT. Health Technol Assess. 2019 Dec;23(64):1–88. 

Jutesten H, Draus J, Frey J, Neovius G, Lindmark G, Buchwald P, Lydrup ML. High risk of permanent stoma after anastomotic leakage in anterior resection for rectal cancer. Colorectal Dis. 2019 Feb;21(2):174–182. 

Olofsson F, Buchwald P, Elmståhl S, Syk I. High Tie or not in Resection for Cancer in the Sigmoid Colon? Scand J Surg. 2019 Sep;108(3):227–232. 

Pieniowski EHA, Palmer GJ, Juul T, Lagergren P, Johar A, Emmertsen KJ, Nordenvall C, Abraham-Nordling M. Low Anterior Resection Syndrome and Quality of Life After Sphincter-Sparing Rectal Cancer Surgery: A Long-term Longitudinal Follow-up. Dis Colon Rectum. 2019 Jan;62(1):14–20. 

Strömberg U, Peterson S, Holmén A, Holmberg E, HultcrantzR, Martling A, Nilbert M. Rational targeting of population groups and residential areas for colorectal cancer screening. Cancer Epidemiology 2019;60: 23–30. 

Sverrisson I, Folkvaljon F, Chabok A, Stattin P, Smedh K, Nikberg M. Anastomotic leakage after anterior resection in patients with rectal cancer previously irradiated for prostate cancer. Eur J Surg Oncol. 2019 Mar;45(3):341–346. 

Söderbäck H, Gunnarsson U, Martling A, Hellman P, Sandblom G. Incidence of wound dehiscence after colorectal cancer surgery: results from a national population-based register for colorectal cancer. Int J Colorectal Dis. 2019 Oct;34(10):1757–1762. 

K Sörelius, J Svensson, P Matthiessen, J Rutegård, M Rutegård A nationwide study on the incidence of mesenteric ischaemia after surgery for rectal cancer demonstrates an association with high arterial ligation. Colorectal Disease 21 (8), 925–931. 

Tivenius M, Näsvall P, Sandblom G. Parastomal hernias causing symptoms or requiring surgical repair after colorectal cancer surgery-a national population-based cohort study. Int J Colorectal Dis. 2019 Jul;34(7):1267–1272. 

Westberg K, Palmer G, Hjern F, Holm T, Martling A. A population-based study on surgical treatment with and without tumour resection in patients with locally recurrent rectal cancer. Br J Surg 2019 May;106(6):790–798. 

Öhlén J, Sawatzky R, Pettersson M, Kenne Sarenmalm E, Håkanson C, Smith F, Wallengren C, Friberg F, Kodeda K, Carlsson E. Preparedness for colorectal cancer surgery and recovery through a person-centred information and communication intervention – a quasi-experimental longitudinal design. PlosOne 2019;14(12): e0225816.